Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr(1)]apelin-13 in humans

[Pyr(1)]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr(1)]apelin-13 metabolism in vivo in rats with no studies examining its stability in humans. We therefore aimed to develop an LC-MS/MS method for detec...

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Udgivet i:Sci Rep
Main Authors: Nyimanu, Duuamene, Kay, Richard G., Sulentic, Petra, Kuc, Rhoda E., Ambery, Philip, Jermutus, Lutz, Reimann, Frank, Gribble, Fiona M., Cheriyan, Joseph, Maguire, Janet J., Davenport, Anthony P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934825/
https://ncbi.nlm.nih.gov/pubmed/31882594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56157-9
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