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Development of hypoallergenic variants of the major horse allergen Equ c 1 for immunotherapy by rational structure based engineering

The use of recombinant allergens is a promising approach in allergen-specific immunotherapy (AIT). Considerable limitation, however, has been the ability of recombinant allergens to activate effector cells leading to allergic reactions. Recombinant hypoallergens with preserved protein folding and ca...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Haka, Jaana, Niemi, Merja H., Mattila, Pekka, Jänis, Janne, Takkinen, Kristiina, Rouvinen, Juha
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934807/
https://ncbi.nlm.nih.gov/pubmed/31882906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56812-1
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