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Development of hypoallergenic variants of the major horse allergen Equ c 1 for immunotherapy by rational structure based engineering

The use of recombinant allergens is a promising approach in allergen-specific immunotherapy (AIT). Considerable limitation, however, has been the ability of recombinant allergens to activate effector cells leading to allergic reactions. Recombinant hypoallergens with preserved protein folding and ca...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Haka, Jaana, Niemi, Merja H., Mattila, Pekka, Jänis, Janne, Takkinen, Kristiina, Rouvinen, Juha
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934807/
https://ncbi.nlm.nih.gov/pubmed/31882906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56812-1
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