Identifying sequence variants contributing to hereditary breast and ovarian cancer in BRCA1 and BRCA2 negative breast and ovarian cancer patients

Families with breast and ovarian cancer are often tested for disease associated sequence variants in BRCA1 and BRCA2. Pathogenic sequence variants (PVs) in these two genes are known to increase breast and ovarian cancer risks in females. However, in most families no PVs are detected in these two gen...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Jarhelle, Elisabeth, Riise Stensland, Hilde Monica Frostad, Hansen, Geir Åsmund Myge, Skarsfjord, Siri, Jonsrud, Christoffer, Ingebrigtsen, Monica, Strømsvik, Nina, Van Ghelue, Marijke
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934654/
https://ncbi.nlm.nih.gov/pubmed/31882575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55515-x
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