Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, and non-BRCA ovarian cancer

BACKGROUND: We conducted a Phase 1 study to evaluate safety and activity of olaparib tablets and oral cyclophosphamide. METHODS: Patients had metastatic breast cancer (BC) or recurrent high-grade serous ovarian cancer (HGSOC), performance status 0–2, and ≤3 lines of prior therapy. Patients were trea...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Lee, Chee Khoon, Scott, Clare, Lindeman, Geoffrey J., Hamilton, Anne, Lieschke, Elizabeth, Gibbs, Emma, Asher, Rebecca, Badger, Heath, Paterson, Robin, Macnab, Lauren, Kwan, Edmond Michael, Francis, Prudence A., Boyle, Frances, Friedlander, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6353881/
https://ncbi.nlm.nih.gov/pubmed/30655615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0349-6
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