Mycobacterium tuberculosis clinical isolates of the Beijing and East-African Indian lineage induce fundamentally different host responses in mice compared to H37Rv

Substantial differences exist in virulence among Mycobacterium tuberculosis strains in preclinical TB models. In this study we show how virulence affects host responses in mice during the first four weeks of infection with a mycobacterial strain belonging to the Beijing, East-African-Indian or Euro-...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mourik, Bas C., de Steenwinkel, Jurriaan E. M., de Knegt, Gerjo J., Huizinga, Ruth, Verbon, Annelies, Ottenhoff, Tom H. M., van Soolingen, Dick, Leenen, Pieter J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934500/
https://ncbi.nlm.nih.gov/pubmed/31882653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56300-6
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