Development of self-assembled multi-arm polyrotaxanes nanocarriers for systemic plasmid delivery in vivo

Polyrotaxane (PRX) is a promising supramolecular carrier for gene delivery. Classic PRX exhibits a linear structure in which the amine-functionalized α-cyclodextrin (CD) is threaded along the entire polyethylene glycol (PEG) backbone. While promising in vitro, the absence of free PEG moieties after...

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Detalhes bibliográficos
Publicado no:Biomaterials
Main Authors: Ji, Ying, Liu, Xiangsheng, Huang, Max, Jiang, Jinhong, Liao, Yu-Pei, Liu, Qi, Chang, Chong Hyun, Liao, Han, Lu, Jianqin, Wang, Xiang, Spencer, Melissa J., Meng, Huan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934403/
https://ncbi.nlm.nih.gov/pubmed/30500723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2018.11.027
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