KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan

BACKGROUND: A constitutively active RAS protein in the absence of stimulation of the epidermal growth factor receptor (EGFR) is the result of mutations in KRAS and NRAS genes. Mutations in the KRAS exon 2 and outside exon 2 have been found to predict the resistance to anti-EGFR monoclonal therapy. A...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Awidi, Muhammad, Ababneh, Nidaa, Shomaf, Maha, Al Fararjeh, Feras, Owaidi, Laila, AlKhatib, Mohammad, Al Tarawneh, Buthaina, Awidi, Abdalla
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934288/
https://ncbi.nlm.nih.gov/pubmed/31881025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226473
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