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KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan
BACKGROUND: A constitutively active RAS protein in the absence of stimulation of the epidermal growth factor receptor (EGFR) is the result of mutations in KRAS and NRAS genes. Mutations in the KRAS exon 2 and outside exon 2 have been found to predict the resistance to anti-EGFR monoclonal therapy. A...
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| Publicado en: | PLoS One |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6934288/ https://ncbi.nlm.nih.gov/pubmed/31881025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226473 |
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