KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan

BACKGROUND: A constitutively active RAS protein in the absence of stimulation of the epidermal growth factor receptor (EGFR) is the result of mutations in KRAS and NRAS genes. Mutations in the KRAS exon 2 and outside exon 2 have been found to predict the resistance to anti-EGFR monoclonal therapy. A...

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Udgivet i:PLoS One
Main Authors: Awidi, Muhammad, Ababneh, Nidaa, Shomaf, Maha, Al Fararjeh, Feras, Owaidi, Laila, AlKhatib, Mohammad, Al Tarawneh, Buthaina, Awidi, Abdalla
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934288/
https://ncbi.nlm.nih.gov/pubmed/31881025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226473
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