Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States

High-resolution Cas9 structures have yet to reveal catalytic conformations due to HNH nuclease domain positioning away from the cleavage site. Nme1Cas9 and Nme2Cas9 are compact nucleases for in vivo genome editing. Here we report structures of meningococcal Cas9 homologs in complex with sgRNA, dsDNA...

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Pubblicato in:Mol Cell
Autori principali: Sun, Wei, Yang, Jing, Cheng, Zhi, Amrani, Nadia, Liu, Chao, Wang, Kangkang, Ibraheim, Raed, Edraki, Alireza, Huang, Xue, Wang, Min, Wang, Jiuyu, Liu, Liang, Sheng, Gang, Yang, Yanhua, Lou, Jizhong, Sontheimer, Erik J., Wang, Yanli
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934045/
https://ncbi.nlm.nih.gov/pubmed/31668930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.09.025
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