Plasmacytoid dendritic cell driven induction of Tregs is strain-specific and correlates with spontaneous acceptance of kidney allografts

BACKGROUND: DBA/2J kidney allografts, but not heart allografts, are spontaneously accepted indefinitely in C57BL/6 (B6) mice, through regulatory tolerance mechanism dependent on Foxp3+ cells. In contrast, B6 kidneys are rejected within a week in DBA/2J recipients. We hypothesized that the tolerogeni...

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Publicat a:Transplantation
Autors principals: Oh, Nicholas A., O’Shea, Thomas, Ndishabandi, Dorothy K., Yuan, Qing, Hong, Shuahuan, Gans, Jared, Ge, Jifu, Gibney, Sean, Chase, Catharine, Yang, Chao, Rosales, Ivy, Shinoda, Kazunobu, Drew, Benjamin, Kojima, Lisa, Russell, Paul S., Madsen, Joren C., Colvin, Robert B., Alessandrini, Alessandro
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933071/
https://ncbi.nlm.nih.gov/pubmed/31335760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000002867
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