Paracrine Fibroblast Growth Factor 1 Functions as Potent Therapeutic Agent for Intrahepatic Cholestasis by Downregulating Synthesis of Bile Acid

Endocrine fibroblast growth factor (FGF) 19 has been shown to be capable of maintaining bile acid (BA) homeostasis and thus hold promise to be a potential therapeutic agent for cholestasis liver disease. However, whether paracrine FGFs possess this BA regulatory activity remains to be determined. In...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Lin, Huan, Zhou, Chuanren, Hou, Yushu, Li, Qi, Qiao, Guanting, Wang, Yang, Huang, Zhifeng, Niu, Jianlou
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933012/
https://ncbi.nlm.nih.gov/pubmed/31920680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01515
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