Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile

AIM: Bile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis. In this study, we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis. METHODS: Cell and animal experiments were given...

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Vydáno v:Front Pharmacol
Hlavní autoři: Xiong, Xiao-Li, Ding, Yan, Chen, Zhi-Lin, Wang, Yao, Liu, Pan, Qin, Huan, Zhou, Li-Shan, Zhang, Ling-Ling, Huang, Juan, Zhao, Lei
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540617/
https://ncbi.nlm.nih.gov/pubmed/31191298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00522
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