Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile

AIM: Bile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis. In this study, we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis. METHODS: Cell and animal experiments were given...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Principais autores: Xiong, Xiao-Li, Ding, Yan, Chen, Zhi-Lin, Wang, Yao, Liu, Pan, Qin, Huan, Zhou, Li-Shan, Zhang, Ling-Ling, Huang, Juan, Zhao, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540617/
https://ncbi.nlm.nih.gov/pubmed/31191298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00522
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