Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile

AIM: Bile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis. In this study, we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis. METHODS: Cell and animal experiments were given...

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Bibliografiska uppgifter
I publikationen:Front Pharmacol
Huvudupphovsmän: Xiong, Xiao-Li, Ding, Yan, Chen, Zhi-Lin, Wang, Yao, Liu, Pan, Qin, Huan, Zhou, Li-Shan, Zhang, Ling-Ling, Huang, Juan, Zhao, Lei
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2019
Ämnen:
Pharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540617/
https://ncbi.nlm.nih.gov/pubmed/31191298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00522
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