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Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization
Developmental genes are often regulated by multiple enhancers exhibiting similar spatiotemporal outputs, which are generally considered redundantly acting though few have been studied functionally. Using CRISPR-Cas9, we created deletions of two enhancers, brk5’ and brk3’, that drive similar but not...
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| Publicado no: | PLoS Genet |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6932828/ https://ncbi.nlm.nih.gov/pubmed/31830033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008525 |
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