Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization

Developmental genes are often regulated by multiple enhancers exhibiting similar spatiotemporal outputs, which are generally considered redundantly acting though few have been studied functionally. Using CRISPR-Cas9, we created deletions of two enhancers, brk5’ and brk3’, that drive similar but not...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Dunipace, Leslie, Ákos, Zsuzsa, Stathopoulos, Angelike
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932828/
https://ncbi.nlm.nih.gov/pubmed/31830033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008525
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