EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production

As a neurotropic virus, human Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease (HFMD) and may develop severe neurological disorders in infants. Toll-like receptor 7 (TLR7) acts as an innate immune receptor and is also a death receptor in the central nervous system (CNS). However, t...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS Pathog
Hauptverfasser: Luo, Zhen, Su, Rui, Wang, Wenbiao, Liang, Yicong, Zeng, Xiaofeng, Shereen, Muhammad Adnan, Bashir, Nadia, Zhang, Qi, Zhao, Ling, Wu, Kailang, Liu, Yingle, Wu, Jianguo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932824/
https://ncbi.nlm.nih.gov/pubmed/31730654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008142
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