High concentrations of middle ear antimicrobial peptides and proteins and proinflammatory cytokines are associated with detection of middle ear pathogens in children with recurrent acute otitis media

Recurrent and chronic otitis media (OM) are often refractory to antibiotics due to bacterial persistence in biofilm within the middle ear. In vitro and in vivo studies have demonstrated that antimicrobial proteins and peptides (AMPs) are bactericidal against otopathogens, indicating potential therap...

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Publicat a:PLoS One
Autors principals: Seppanen, Elke J., Thornton, Ruth B., Corscadden, Karli J., Granland, Caitlyn M., Hibbert, Julie, Fuery, Angela, Wiertsema, Selma P., Vijayasekaran, Shyan, Coates, Harvey L., Jacoby, Peter, Currie, Andrew, Richmond, Peter C., Kirkham, Lea-Ann S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932785/
https://ncbi.nlm.nih.gov/pubmed/31877198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227080
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