High concentrations of middle ear antimicrobial peptides and proteins and proinflammatory cytokines are associated with detection of middle ear pathogens in children with recurrent acute otitis media

Recurrent and chronic otitis media (OM) are often refractory to antibiotics due to bacterial persistence in biofilm within the middle ear. In vitro and in vivo studies have demonstrated that antimicrobial proteins and peptides (AMPs) are bactericidal against otopathogens, indicating potential therap...

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Bibliographic Details
Published in:PLoS One
Main Authors: Seppanen, Elke J., Thornton, Ruth B., Corscadden, Karli J., Granland, Caitlyn M., Hibbert, Julie, Fuery, Angela, Wiertsema, Selma P., Vijayasekaran, Shyan, Coates, Harvey L., Jacoby, Peter, Currie, Andrew, Richmond, Peter C., Kirkham, Lea-Ann S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932785/
https://ncbi.nlm.nih.gov/pubmed/31877198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227080
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