α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway

The production of reactive oxygen species (ROS) by cisplatin is one of the major mechanisms of cisplatin-induced cytotoxicity. We examined the preventive effect of α-lipoic acid (LA) on cisplatin-induced toxicity via its antioxidant effects on in vitro and ex vivo culture systems. To elucidate the m...

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Vydáno v:PLoS One
Hlavní autoři: Lee, Joohyung, Jung, So-Young, Yang, Keum-Jin, Kim, Yoonho, Lee, Dohee, Lee, Min Hyeong, Kim, Dong-Kee
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932784/
https://ncbi.nlm.nih.gov/pubmed/31877176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226769
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