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Correction for QT/RR Hysteresis in the Assessment of Drug‐Induced QTc Changes—Cardiac Safety of Gadobutrol

Background: The so‐called thorough QT/QTc (TQT) studies required for every new pharmaceutical compound are negative if upper single‐sided 95% confidence interval (CI) of placebo and baseline corrected QTc prolongation is <10 ms. This tight requirement has many methodological implications. If the...

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Detalhes bibliográficos
Publicado no:Ann Noninvasive Electrocardiol
Main Authors: Malik, Marek, Hnatkova, Katerina, Schmidt, Anna, Smetana, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Inc 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932186/
https://ncbi.nlm.nih.gov/pubmed/19614635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1542-474X.2009.00304.x
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