Use of ECG Restitution (Beat‐to‐Beat QT‐TQ Interval Analysis) to Assess Arrhythmogenic Risk of QTc Prolongation with Guanfacine

BACKGROUND: Guanfacine (Intuniv) is a centrally active alpha‐2A adrenergic agonist for the new indication of attention‐deficit/hyperactivity disorder. QTc (QTcF and QTcNi) was prolonged at both therapeutic (4 mg) and supratherapeutic (8 mg) doses of a thorough QT study even though guanfacine has had...

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Vydáno v:Ann Noninvasive Electrocardiol
Hlavní autoři: Fossa, Anthony A., Zhou, Meijian, Robinson, Antoine, Purkayastha, Jaideep, Martin, Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2014
Témata:
Cardiac Safety
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6931917/
https://ncbi.nlm.nih.gov/pubmed/25200912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/anec.12202
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