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Recombinant C1q variants modulate macrophage responses but do not activate the classical complement pathway

Complement protein C1q plays a dual role in a number of inflammatory diseases such as atherosclerosis. While in later stages classical complement pathway activation by C1q exacerbates disease progression, C1q also plays a beneficial role in early disease. Independent of its role in complement activa...

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Bibliographic Details
Published in:Mol Immunol
Main Authors: Espericueta, Victoria, Manughian-Peter, Ayla O., Bally, Isabelle, Thielens, Nicole M., Fraser, Deborah A.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6931381/
https://ncbi.nlm.nih.gov/pubmed/31739194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2019.10.008
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