Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors

Simultaneous inhibition of multiple molecular targets is an established strategy to improve the continuance of clinical response to therapy. Here, we screened 49 molecules with dual nanomolar inhibitory activity against BRD4 and PLK1, best classified as dual kinase-bromodomain inhibitors, in pediatr...

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Publicado no:Transl Oncol
Main Authors: Timme, Natalie, Han, Youjia, Liu, Shuai, Yosief, Hailemichael O., García, Heathcliff Dorado, Bei, Yi, Klironomos, Filippos, MacArthur, Ian C., Szymansky, Annabell, von Stebut, Jennifer, Bardinet, Victor, Dohna, Constantin, Künkele, Annette, Rolff, Jana, Hundsdörfer, Patrick, Lissat, Andrej, Seifert, Georg, Eggert, Angelika, Schulte, Johannes H., Zhang, Wei, Henssen, Anton G.
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2019
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6931204/
https://ncbi.nlm.nih.gov/pubmed/31869746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.09.013
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