Prohibitin promotes dedifferentiation and is a potential therapeutic target in neuroblastoma

Gain of the long arm of chromosome 17 (17q) is a cytogenetic hallmark of high-risk neuroblastoma, yet its contribution to neuroblastoma pathogenesis remains incompletely understood. Combining whole-genome and RNA sequencing of neuroblastomas, we identified the prohibitin (PHB) gene as highly express...

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發表在:JCI Insight
Main Authors: MacArthur, Ian C., Bei, Yi, Garcia, Heathcliff Dorado, Ortiz, Michael V., Toedling, Joern, Klironomos, Filippos, Rolff, Jana, Eggert, Angelika, Schulte, Johannes H., Kentsis, Alex, Henssen, Anton G.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2019
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542629/
https://ncbi.nlm.nih.gov/pubmed/30998507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127130
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