PIK3CA and KRAS Amplification in Esophageal Adenocarcinoma and their Impact on the Inflammatory Tumor Microenvironment and Prognosis

Gene amplifications of PIK3CA or KRAS induce a downstream activation of the AKT-mTOR or RAF-ERK-pathways. Interactions of the active AKT pathway have been implicated in the inflammatory tumor microenvironment. Nothing is known about these interactions or prognostic power in esophageal adenocarcinoma...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Essakly, Ahlem, Loeser, Heike, Kraemer, Max, Alakus, Hakan, Chon, Seung-Hun, Zander, Thomas, Buettner, Reinhard, Hillmer, Axel M., Bruns, Christiane J., Schroeder, Wolfgang, Gebauer, Florian, Quaas, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2019
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6931191/
https://ncbi.nlm.nih.gov/pubmed/31865178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.10.013
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