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Study on degradation kinetics of epalrestat in aqueous solutions and characterization of its major degradation products under stress degradation conditions by UHPLC-PDA-MS/MS

Drug stability is closely related to drug safety and needs to be considered in the process of drug production, package and storage. To investigate the stability of epalrestat, a carboxylic acid derivative, a reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed in this...

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Detalhes bibliográficos
Publicado no:J Pharm Anal
Main Authors: Sun, Hong, Liu, Suyan, Gao, Xun, Xiong, Zhili, He, Zhonggui, Zhao, Longshan
Formato: Artigo
Idioma:Inglês
Publicado em: Xi'an Jiaotong University 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6931074/
https://ncbi.nlm.nih.gov/pubmed/31890342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2018.08.002
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