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Mechanisms of Dupilumab
The Th2 cytokines interleukin 4 (IL-4) and IL-13 and the heterodimeric IL-4 receptor (IL-4R) complexes that they interact with play a key role in the pathogenesis of allergic disorders. Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL-4 receptor alpha chain (IL-4Rα), common to b...
Gardado en:
| Publicado en: | Clin Exp Allergy |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6930967/ https://ncbi.nlm.nih.gov/pubmed/31505066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cea.13491 |
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