Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

Bayesian forecasting for dose individualization of prophylactic factor VIII replacement therapy using pharmacokinetic samples is challenged by large interindividual variability in the bleeding risk. A pharmacokinetic‐repeated time‐to‐event model‐based forecasting approach was developed to contrast t...

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Publicat a:CPT Pharmacometrics Syst Pharmacol
Autors principals: Abrantes, João A., Solms, Alexander, Garmann, Dirk, Nielsen, Elisabet I., Jönsson, Siv, Karlsson, Mats O.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930854/
https://ncbi.nlm.nih.gov/pubmed/31668021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12464
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