Superior Treg-Expanding Properties of a Novel Dual-Acting Cytokine Fusion Protein

Autoimmune diseases are caused by uncontrolled endogenous immune responses against healthy cells. They may develop due to an impaired function of regulatory T cells (Tregs), which normally suppress self-specific effector immune cells. Interleukin 2 (IL-2) and tumor necrosis factor (TNF) have been id...

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Vydáno v:Front Pharmacol
Hlavní autoři: Padutsch, Tanja, Sendetski, Maksim, Huber, Carina, Peters, Nathalie, Pfizenmaier, Klaus, Bethea, John R., Kontermann, Roland E., Fischer, Roman
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930692/
https://ncbi.nlm.nih.gov/pubmed/31920671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01490
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