Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening

Cancers express tryptophan catabolising enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) to produce immunosuppressive tryptophan metabolites that undermine patients’ immune systems, leading to poor disease outcomes. Both enzymes are validated targets for cancer immu...

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發表在:Molecules
Main Authors: Sari, Suat, Tomek, Petr, Leung, Euphemia, Reynisson, Jóhannes
格式: Artigo
語言:Inglês
出版: MDPI 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930675/
https://ncbi.nlm.nih.gov/pubmed/31795096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24234346
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