The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors

Colchicine site ligands suffer from low aqueous solubility due to the highly hydrophobic nature of the binding site. A new strategy for increasing molecular polarity without exposing polar groups—termed masked polar group incorporation (MPGI)—was devised and applied to nitrogenated combretastatin an...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: González, Myriam, Ellahioui, Younes, Álvarez, Raquel, Gallego-Yerga, Laura, Caballero, Esther, Vicente-Blázquez, Alba, Ramudo, Laura, Marín Folgado, Miguel, Sanz, Cristina, Medarde, Manuel, Pelaéz, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930638/
https://ncbi.nlm.nih.gov/pubmed/31779228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24234319
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