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Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1

The poor survival rate of pancreatic cancer is still a major challenge for the clinicians and their patients. In this study, we evaluated the efficacy of metformin, an inhibitor of oxidative phosphorylation, in combination with LW6, which impairs malate dehydrogenase 2 activities, in treating pancre...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Cancer
Hauptverfasser: Zhang, Xianbin, Liu, Peng, Shang, Yuru, Kerndl, Hagen, Kumstel, Simone, Gong, Peng, Vollmar, Brigitte, Zechner, Dietmar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930432/
https://ncbi.nlm.nih.gov/pubmed/31897243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.33029
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