Molecular Landscape of Anti-Drug Antibodies Reveals the Mechanism of the Immune Response Following Treatment With TNFα Antagonists

Drugs formulated from monoclonal antibodies (mAbs) are clinically effective in various diseases. Repeated administration of mAbs, however, elicits an immune response in the form of anti-drug-antibodies (ADA), thereby reducing the drug's efficacy. Notwithstanding their importance, the molecular...

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Udgivet i:Front Immunol
Main Authors: Vaisman-Mentesh, Anna, Rosenstein, Shai, Yavzori, Miri, Dror, Yael, Fudim, Ella, Ungar, Bella, Kopylov, Uri, Picard, Orit, Kigel, Aya, Ben-Horin, Shomron, Benhar, Itai, Wine, Yariv
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930160/
https://ncbi.nlm.nih.gov/pubmed/31921180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02921
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