Molecular Landscape of Anti-Drug Antibodies Reveals the Mechanism of the Immune Response Following Treatment With TNFα Antagonists

Drugs formulated from monoclonal antibodies (mAbs) are clinically effective in various diseases. Repeated administration of mAbs, however, elicits an immune response in the form of anti-drug-antibodies (ADA), thereby reducing the drug's efficacy. Notwithstanding their importance, the molecular...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Vaisman-Mentesh, Anna, Rosenstein, Shai, Yavzori, Miri, Dror, Yael, Fudim, Ella, Ungar, Bella, Kopylov, Uri, Picard, Orit, Kigel, Aya, Ben-Horin, Shomron, Benhar, Itai, Wine, Yariv
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930160/
https://ncbi.nlm.nih.gov/pubmed/31921180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02921
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