How C-terminal additions to insulin B-chain fragments create super-agonists for T cells in mouse and human type-1 diabetes.

In type 1 diabetes (T1D), proinsulin is a major autoantigen and the insulin B:9–23 peptide contains epitopes for CD4 T cells in both mice and humans. This peptide requires C-terminal mutations for uniform binding in the proper position within the mouse IA(g7) or human DQ8 MHCII peptide grooves and f...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Immunol
Autors principals: Wang, Yang, Sosinowski, Tomasz, Novikov, Andrey, Crawford, Frances, White, Janice, Jin, Niyun, Liu, Zikou, Zou, Jinhao, Neau, David, Davidson, Howard W., Nakayama, Maki, Kwok, William W., Gapin, Laurent, Marrack, Philippa, Kappler, John W., Dai, Shaodong
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929690/
https://ncbi.nlm.nih.gov/pubmed/30952805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aav7517
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars