How C-terminal additions to insulin B-chain fragments create super-agonists for T cells in mouse and human type-1 diabetes.

In type 1 diabetes (T1D), proinsulin is a major autoantigen and the insulin B:9–23 peptide contains epitopes for CD4 T cells in both mice and humans. This peptide requires C-terminal mutations for uniform binding in the proper position within the mouse IA(g7) or human DQ8 MHCII peptide grooves and f...

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Vydáno v:Sci Immunol
Hlavní autoři: Wang, Yang, Sosinowski, Tomasz, Novikov, Andrey, Crawford, Frances, White, Janice, Jin, Niyun, Liu, Zikou, Zou, Jinhao, Neau, David, Davidson, Howard W., Nakayama, Maki, Kwok, William W., Gapin, Laurent, Marrack, Philippa, Kappler, John W., Dai, Shaodong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929690/
https://ncbi.nlm.nih.gov/pubmed/30952805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aav7517
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