T-bet transcription factor promotes antibody secreting cell differentiation by limiting the inflammatory effects of IFNγ on B cells

Although viral infections elicit robust interferon-γ (IFNγ) and long-lived antibody secreting cell (ASC) responses, the roles for IFNγ and IFNγ-induced transcription factors (TFs) in ASC development are unclear. We showed that B cell intrinsic expression of IFNγR and the IFNγ-induced TF T-bet were r...

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Pubblicato in:Immunity
Autori principali: Stone, Sara L., Peel, Jessica, Scharer, Christopher D., Risley, Christopher A., Chisolm, Danielle A., Schultz, Michael D., Yu, Bingfei, Ballesteros-Tato, André, Wojciechowski, Wojciech, Mousseau, Betty, Misra, Ravi S., Hanidu, Adedayo, Jiang, Huiping, Qi, Zhenhao, Boss, Jeremy M., Randall, Troy D., Brodeur, Scott R., Goldrath, Ananda W., Weinmann, Amy S., Rosenberg, Alexander F., Lund, Frances E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929688/
https://ncbi.nlm.nih.gov/pubmed/31076359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.04.004
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