Inhibition of DRP-1-Dependent Mitophagy Promotes Cochlea Hair Cell Senescence and Exacerbates Age-Related Hearing Loss

Background: Mitochondrial dysfunction is considered to contribute to the development of age-related hearing loss (AHL). The regulation of mitochondrial function requires mitochondrial quality control, which includes mitophagy and dynamics. Dynamin-related Protein 1 (DRP-1) is believed to play a cent...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Lin, Hanqing, Xiong, Hao, Su, Zhongwu, Pang, Jiaqi, Lai, Lan, Zhang, Huasong, Jian, Bingquan, Zhang, Weijian, Zheng, Yiqing
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Cellular Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929675/
https://ncbi.nlm.nih.gov/pubmed/31920551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00550
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