Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing

Synucleinopathies are mostly sporadic neurodegenerative disorders of partly unexplained aetiology, and include Parkinson’s disease (PD) and multiple system atrophy (MSA). We have further investigated our recent finding of somatic SNCA (α-synuclein) copy number variants (CNVs, specifically gains) in...

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Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: Perez-Rodriguez, Diego, Kalyva, Maria, Leija-Salazar, Melissa, Lashley, Tammaryn, Tarabichi, Maxime, Chelban, Viorica, Gentleman, Steve, Schottlaender, Lucia, Franklin, Hannah, Vasmatzis, George, Houlden, Henry, Schapira, Anthony H. V., Warner, Thomas T., Holton, Janice L., Jaunmuktane, Zane, Proukakis, Christos
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929293/
https://ncbi.nlm.nih.gov/pubmed/31870437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0873-5
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