Heterozygous Ldlr-Deficient Hamster as a Model to Evaluate the Efficacy of PCSK9 Antibody in Hyperlipidemia and Atherosclerosis

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in cholesterol homeostasis and atherogenesis. However, there are only limited rodent models, with a functional low-density lipoprotein receptor (LDLR) pathway and cholesteryl ester transfer protein (CETP) to evaluate the drug can...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Wu, Yue, Xu, Ming-Jiang, Cao, Zhiyou, Yang, Chun, Wang, Jinjie, Wang, Bijue, Liu, Jian, Wang, Yuhui, Xian, Xunde, Zhang, Fang, Liu, George, Chen, Xiaoli
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929182/
https://ncbi.nlm.nih.gov/pubmed/31779098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20235936
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