LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis

Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease caused mainly by LDL receptor (Ldlr) gene mutations. Unlike FH patients, heterozygous Ldlr knockout (KO) mice do not show a dominant FH trait. Hamsters, like humans, have the cholesteryl ester transfer protein, intestine-onl...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Guo, Xin, Gao, Mingming, Wang, Yunan, Lin, Xiao, Yang, Liu, Cong, Nathan, An, Xiangbo, Wang, Feng, Qu, Kai, Yu, Liqing, Wang, Yuhui, Wang, Jinjie, Zhu, Haibo, Xian, Xunde, Liu, George
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828369/
https://ncbi.nlm.nih.gov/pubmed/29289533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.12.013
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