LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis

Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease caused mainly by LDL receptor (Ldlr) gene mutations. Unlike FH patients, heterozygous Ldlr knockout (KO) mice do not show a dominant FH trait. Hamsters, like humans, have the cholesteryl ester transfer protein, intestine-onl...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Guo, Xin, Gao, Mingming, Wang, Yunan, Lin, Xiao, Yang, Liu, Cong, Nathan, An, Xiangbo, Wang, Feng, Qu, Kai, Yu, Liqing, Wang, Yuhui, Wang, Jinjie, Zhu, Haibo, Xian, Xunde, Liu, George
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828369/
https://ncbi.nlm.nih.gov/pubmed/29289533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.12.013
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