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QSAR Models for Predicting Five Levels of Cellular Accumulation of Lysosomotropic Macrocycles
Drugs that accumulate in lysosomes reach very high tissue concentrations, which is evident in the high volume of distribution and often lower clearance of these compounds. Such a pharmacokinetic profile is beneficial for indications where high tissue penetration and a less frequent dosing regime is...
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| Publicado no: | Int J Mol Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6928787/ https://ncbi.nlm.nih.gov/pubmed/31779113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20235938 |
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