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QSAR Models for Predicting Five Levels of Cellular Accumulation of Lysosomotropic Macrocycles

Drugs that accumulate in lysosomes reach very high tissue concentrations, which is evident in the high volume of distribution and often lower clearance of these compounds. Such a pharmacokinetic profile is beneficial for indications where high tissue penetration and a less frequent dosing regime is...

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Dades bibliogràfiques
Publicat a:Int J Mol Sci
Autors principals: Norinder, Ulf, Munic Kos, Vesna
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928787/
https://ncbi.nlm.nih.gov/pubmed/31779113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20235938
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