Differences in microRNA-29 and Pro-fibrotic Gene Expression in Mouse and Human Hypertrophic Cardiomyopathy

Background: Hypertrophic cardiomyopathy (HCM) is characterized by myocyte hypertrophy and fibrosis. Studies in two mouse models (R92W-TnT/R403Q-MyHC) at early HCM stage revealed upregulation of endothelin (ET1) signaling in both mutants, but TGFβ signaling only in TnT mutants. Dysregulation of miR-2...

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Detalhes bibliográficos
Publicado no:Front Cardiovasc Med
Main Authors: Liu, Yamin, Afzal, Junaid, Vakrou, Styliani, Greenland, Gabriela V., Talbot, C. Conover, Hebl, Virginia B., Guan, Yufan, Karmali, Rehan, Tardiff, Jil C., Leinwand, Leslie A., Olgin, Jeffrey E., Das, Samarjit, Fukunaga, Ryuya, Abraham, M. Roselle
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Cardiovascular Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928121/
https://ncbi.nlm.nih.gov/pubmed/31921893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2019.00170
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