Conformation Transition of Intracellular Part of Glucagon Receptor in Complex With Agonist Glucagon by Conventional and Accelerated Molecular Dynamics Simulations

The inactive conformations of glucagon receptor (GCGR) are widely reported by crystal structures that support the precision structure for drug discovery of type 2 diabetes. The previous study shows that the intracellular part is open in the glucagon-bound GCGR (glu-GCGR) and closed in the apo-GCGR b...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Bai, Qifeng, Tan, Shuoyan, Pérez-Sánchez, Horacio, Feng, Haixia, Feng, Liya, Liu, HuanXiang, Yao, Xiaojun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928006/
https://ncbi.nlm.nih.gov/pubmed/31921774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00851
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