Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations

Activation of human free fatty acid receptor 1 (FFAR1, also called hGPR40) enhances insulin secretion in a glucose-dependent manner. Hence, the development of selective agonist targeting hGPR40 has been proposed as a therapeutic strategy of type 2 diabetes mellitus. Some agonists targeting hGPR40 we...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: An, Xiaoli, Bai, Qifeng, Bing, Zhitong, Liu, Huanxiang, Yao, Xiaojun
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313488/
https://ncbi.nlm.nih.gov/pubmed/34377364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2021.07.008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados