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A new in vitro model of polymyositis reveals CD8(+) T cell invasion into muscle cells and its cytotoxic role
OBJECTIVES: The hallmark histopathology of PM is the presence of CD8(+) T cells in the non-necrotic muscle cells. The aim of this study was to clarify the pathological significance of CD8(+) T cells in muscle cells. METHODS: C2C12 cells were transduced retrovirally with the genes encoding MHC class...
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| Veröffentlicht in: | Rheumatology (Oxford) |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6927901/ https://ncbi.nlm.nih.gov/pubmed/31257434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kez248 |
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