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Neutrophils remain detrimentally active in hydroxyurea-treated patients with sickle cell disease

Neutrophilia is a feature of sickle cell disease (SCD) that has been consistently correlated with clinical severity and has been shown to remain highly activated even at steady state. In addition to induction of fetal hemoglobin (HbF), hydroxyurea (HU) leads to reduction in neutrophil count and thei...

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Publicat a:PLoS One
Autors principals: Barbu, Emilia Alina, Dominical, Venina M., Mendelsohn, Laurel, Thein, Swee Lay
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927657/
https://ncbi.nlm.nih.gov/pubmed/31869367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226583
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