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Self-association of human beta-galactocerebrosidase: Dependence on pH, salt, and surfactant

Krabbe disease, also known as globoid cell leukodystrophy, is a rare genetic neurodegenerative disease caused by a deficiency of the galactocerebrosidase enzyme. To understand the association status of human beta-galactocerebrosidase (hGALC) in solution, we employed analytical ultracentrifugation (A...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Lee, Eunhee, Salamat-Miller, Nazila, Stafford, Walter F., Taylor, Katherine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927645/
https://ncbi.nlm.nih.gov/pubmed/31869371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226618
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