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pH-Dependent Self-Assembly of Polyalanine Peptides

Polyalanine expansions in the nuclear RNA-binding protein PABP2 induce misfolding and aggregation of the protein into insoluble inclusions in muscle tissues and cell nuclei, leading to the disease oculopharyngeal muscular dystrophy (OPMD). We have explored the effect of solvent conditions and alanin...

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Bibliografski detalji
Glavni autori: Giri, Kalyan, Bhattacharyya, Nitai P., Basak, Soumen
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1697844/
https://ncbi.nlm.nih.gov/pubmed/17040985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.091769
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