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pH-Dependent Self-Assembly of Polyalanine Peptides
Polyalanine expansions in the nuclear RNA-binding protein PABP2 induce misfolding and aggregation of the protein into insoluble inclusions in muscle tissues and cell nuclei, leading to the disease oculopharyngeal muscular dystrophy (OPMD). We have explored the effect of solvent conditions and alanin...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Biophysical Society
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1697844/ https://ncbi.nlm.nih.gov/pubmed/17040985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.091769 |
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